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Historically, men with high-risk prostate cancer were believed to have low survival rates after definitive treatment with either surgery or radiation. However, long-term results of dose-escalated radiotherapy of doses ≥ 75.6 Gy, along with long-term androgen deprivation therapy (ADT), demonstrate 5-year survival rate of 92%, 5-year biochemical control rate of 82%, and symptomatic local failure rate of 0%. Death from prostate cancer was only 5.5% at 10 years in men treated with high-dose radiation therapy and ADT.
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In a study of men in the Veterans Affairs health care system with low serum testosterone levels, the use of testosterone therapy was associated with an increased risk of mortality, myocardial infarction, or ischemic stroke.
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The use of dabigatran in patients with mechanical heart valves compared with patients receiving warfarin was associated with increased rates of thromboembolic and bleeding complications, thus demonstrating no benefit and an excess risk.
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Frequent premature ventricular contractions (PVCs) may lead to a cardiomyopathy or worsen a pre-existing cardiomyopathy.
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Since the initial description of variant angina by Prinzmetal in the late 1950s and the later confirmation of coronary artery spasm as its cause, clinicians have sought a means of reliably testing for this entity.
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The transradial approach to cardiac catheterization has been steadily gaining ground over the past several years due to advantages over the femoral approach in terms of bleeding risk, vascular injury, procedural cost, and patient comfort.
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Atrial fibrillation (AF) is common and catheter ablation has become widely available.
